Glucose homeostasis in human body is regulated by number of hormones(insulin, glucagon etc.) through number of mechanisms.Gastrointestinal tract plays a vital role in maintaining normal blood glucose levels by secreting hormones like "glucagon like peptide" (GLP) and "glucose dependent insulinotropic polypeptide" (GIP).These hormones are known as incretins and regulate glucose homeostasis by:-

1. Stimulating insulin secretion.

2. Inhibiting glucagon synthesis.

3. Delaying gastric emptying.

Incretins secreted in gastrointestinal tract are rapidly inactivated by the enzyme called "dipeptidyl peptidase -4 (DPP-4).Gliptins are novel oral anti-diabetic medication that prolong the actions of endogenous incretins (GLP) by antagonising the effect of DPP-4.Gliptins that are currently in use include vildagliptin ,sitagliptin and saxagliptin.Gliptins are prescribed for Diabetes type-2 as monotherapy or in combination with other oral hypoglcemic drugs.Some of the adverse effects of Gliptins may include headache,dizziness,sore throat and running nose.


The information provided on is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her health professional. This information is solely for informational and educational purposes. The publication of this information does not constitute the practice of medicine, and this information does not replace the advice of your physician or other health care provider. Neither the owners or employees of nor the author(s) of site content take responsibility for any possible consequences from any treatment, procedure, exercise, dietary modification, action or application of medication which results from reading this site. Always speak with your primary health care provider before engaging in any form of self treatment. Please see our Legal Statement for further information. Social


Diabetes Poll

Are you currently using oral medication to help control your diabetes?:
Total votes: 1110