Metformin Doesn't Work for Overweight Teens With Type 1 Diabetes
Overweight adolescents who have type 1 diabetes may not necessarily benefit from taking metformin for glycemic control, a new study reports.
Youth with type 1 diabetes can face particular challenges if they have extra weight, the study authors report, since using insulin therapy can cause further metabolic problems in developing bodies that are already hormonally chaotic.
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The current study may be the first to provide conclusive evidence that meformin does not offer substantial benefits to overweight teens battling type 1 diabetes.
Not effective against heart disease, either
While metformin was associated with reductions in weight gain and body fat, researchers say the results aren't significant enough to merit the drug being used for insulin control in youth. Moreover, metformin failed to improve biochemical risk factors for conditions like heart disease or high blood pressure in the teens.
"These results do not support prescribing metformin to adolescents to improve glycemic control," the researchers said.
According to the American Diabetes Association, youth with type 1 diabetes have an increased risk for early death and cardiovascular problems.
Previous research has shown metformin doesn't positively affect long-term glucose levels in children with type 1 diabetes.
Source: The JAMA Network Journals
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