Reducing blood sugar works best with drug duo, study finds

The combined effects of metformin and SGLT2 inhibitors work better than one drug alone to help reduce blood sugar in people with Type 2 diabetes, report researchers in the journal Diabetes.

The two substances appear to reinforce the beneficial effects of each other, suggesting this approach could have significant implications for the prevention, diagnosis and treatment of diabetes.

Medications work together to lower blood sugar levels

SGLT2 inhibitors help the body eliminate sugar in the urine, which reduces blood sugar. Yet the body reacts to this loss by increasing sugar production in the liver. Metformin addresses this problem by slowing down the body's sugar production. Together, the two substances can create a drop in blood sugar that lasts longer than the effects of just one of the drugs.

"The combination of drugs effectively reduces the blood sugar, and particularly also the blood sugar peaks after meals," said Dr. Susanne Neschen, lead author of the study. "In diabetic mice, the double therapy produced an improvement in the long-term blood sugar level HbA1c within only two weeks."

Since the combo also has been shown to produce minimal side effects, it could be helpful for individuals who have had problems with other diabetes drugs.

Source: Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health

Get a Free Diabetes Meal Plan

Get a free 7-Day Diabetes Meal Plan from Constance Brown-Riggs who is a Registered Dietitian-Certified Diabetes Educator and who is also a national spokesperson for the American Dietetic Association.

Just enter in your email below to download your free Diabetes Meal Plan.

By clicking Submit, you agree to send your info to BattleDiabetes.com who, in addition to 3rd party partners, may contact you with updates, products and information and we agree to use it according to our privacy policy and terms and conditions.

More Articles

More Articles

Scientists have discovered that a single gene forms a common link between type 2 diabetes and...

Natural supplements like cinnamon extract and apple cider vinegar could hold the key to lowering blood sugar levels, according to a recent...

Natural supplements like cinnamon extract and apple cider vinegar could hold the key to lowering blood sugar levels, according to a recent...

Could a person's risk for type 2 diabetes be written in their genes?

According to a study recently published in ...

Women who frequently shift around their sleeping hours could have worse metabolic health outcomes than their peers who stick with a...

The presence of the hormone leptin may hinder prenatal development, which could explain the origin of type 2 diabetes, according to...

An analysis of fossilized Native American feces shows that our ancestors ate up to sixteen times the fiber that we do today, but our...

Managing diabetes is hugely challenging for people of any age, but a new study suggests that young people may suffer all the more....

Disruptions to the gut’s ecosystem could be a future symptom facing young children who take antibiotics, which makes them more susceptible...

Breastfeeding a newborn holds many benefits for mommy and baby; it reduces the baby's risk for colds and viruses, it helps his bones (and yours)...

Fans of the Dexcom G5 Mobile have something to smile about.

At yesterday's hearing with the U.S. Food and Drug...

If you start your day with a cup of tea and end it with a glass of red wine, your blood sugar may thank you.

At least that...

As medical experts continue to debate whether or not "healthy obesity" can even exist, one new study suggests that risk for heart disease...

For years, type 1 diabetics have been anxiously waiting for that medical marvel that can stop the constant injections: the artificial...

“Low-fat” has been the battle cry of the health-conscious for over ‌‌‌‌‌‌‌‌‌‌‌...