Low Level of Hormone May increase Diabetes Risk

A team of researchers affiliated with Scripps Research Institute has recently shown that metabolic diseases, such as diabetes, may be linked to low levels of the hormone Adropin. These findings may eventually lead to the production of new therapies for diabetics and those with pre-diabetic symptoms. The study was published in the online version of The Journal of Clinical Endocrinology & Metabolism.

Researchers previously examined obese, insulin-resistant mice and found that the hormone was low in this group. This new study involved 130 patients, 45 men and 85 women, and found that lower levels of adropin were associated with higher "metabolic syndrome risk factor" score. According to Scripps Research Associate Professor Andrew Butler:

"The results of this clinical study suggest that low levels of adropin may be a factor increasing risk for developing metabolic disorders associated with obesity and insulin resistance, which could then lead to diseases such as type 2 diabetes."

"Adropin" the Bucket

There is still much to discover about the link between adropin and metabolic disease. Further study found that gastric bypass temporarily increased the level of adropin, but after 12 months it returned to normal levels. Also, women who were of normal weight also had lower levels of the hormone than men of normal weight. Men who were considered overweight had lower levels of the hormone. Researchers are still not sure why the gender differences in adropin occur, but Butler says, “the link between low levels of adropin and increased metabolic risk was observed in both sexes; The impact is there, irrespective of gender."

The American Heart Association published The American College of Cardiology estimates that nearly 50 million Americans have some sort of metabolic disorder, including diseases such as diabetes and insulin resistance. There is much to explore in this area, but the findings are exciting. With additional research, new and more effective treatments may be possible. That is good news to those that have the disease, and the families who love them.


Sources:
http://circ.ahajournals.org/content/122/11_suppl_1/S185.full
http://www.medicalnewstoday.com/articles/249180.php
http://www.news-medical.net/news/20120816/Low-adropin-levels-may-increas...
http://www.medicalnewstoday.com/releases/249095.php

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